Document Detail

The role of metabolic syndrome components and adipokines in insulin resistance in prepubertal children.
MedLine Citation:
PMID:  21823525     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Insulin resistance has a central role in the pathophysiology of cardiovascular atherosclerotic disease. Adipose tissue is of capital importance in view of its production of adipokines. The present study aims to determine the association of metabolic syndrome components, which constitute risk factors for cardiovascular atherosclerotic disease, and leptin and adiponectin with insulin resistance in prepubertal children.
METHODS: We conducted a cross-sectional study involving 197 children. Of these, 112 children were obese, 36 were overweight and 49 had normal weight. The association of sex, waist circumference, Acanthosis nigricans, age, BMI Z-score, serum lipids, leptin and adipocytokines with insulin resistance [defined as the homeostatic model assessment for insulin resistance (HOMA-IR) index higher than or equal to 2.5] was investigated using logistic regression.
RESULTS: There was positive association of sex (female), age, BMI Z-score, triglycerides and leptin with insulin resistance (p<0.05).
CONCLUSION: Among the conventional components of metabolic syndrome, the role of BMI Z-score and triglycerides stands out in insulin resistance of prepubertal children. Sex (female), age and leptin also showed to be of major importance.
Isabel Rey Madeira; Maria Alice Neves Bordallo; Cecilia Noronha Miranda Carvalho; Fernanda Mussi Gazolla; Flavio Moutinho de Souza; Haroldo José de Matos; Marcos Antônio Borges
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  24     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-09     Completed Date:  2011-08-30     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  289-95     Citation Subset:  IM    
Department of Pediatrics, FCM, UERJ, Brazil.
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MeSH Terms
Acanthosis Nigricans / complications,  physiopathology
Adipokines / physiology*
Adiponectin / physiology
Body Weight / physiology
Cardiovascular Diseases / etiology,  physiopathology
Case-Control Studies
Child, Preschool
Cross-Sectional Studies
Insulin Resistance / physiology*
Leptin / physiology
Lipids / blood
Logistic Models
Metabolic Syndrome X / complications,  physiopathology*
Obesity / complications,  physiopathology
Overweight / complications,  physiopathology
Risk Factors
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adipokines; 0/Adiponectin; 0/Leptin; 0/Lipids

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