Document Detail


A role for menstruation in preconditioning the uterus for successful pregnancy.
MedLine Citation:
PMID:  19136085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Menstruation is widely viewed as serving no purpose other than to reinitiate the endometrial cycle in the absence of pregnancy. Yet, it is striking that cyclic endometrial decidualization followed by menstrual shedding is confined to the few species, including human beings, where placenta formation entails deep trophoblast invasion of maternal tissues and its vasculature. Both menstruation and pregnancy are inflammatory conditions that cause a degree of physiological ischemia-reperfusion tissue injury, albeit much more so in pregnancy. Thus, the emergence of cyclic menstruation may not have been an evolutionary coincidence but serves to protect uterine tissues from the profound hyperinflammation and oxidative stress associated with deep placentation, a process known as preconditioning. The concept of menstrual preconditioning provides a novel paradigm for understanding how reproductive disorders impact on pregnancy outcome. For example, endometriosis could be viewed as a disorder of exaggerated menstrual preconditioning that confers protection against placentation-related disorders, such as preeclampsia.
Authors:
Jan J Brosens; Malcolm G Parker; Angus McIndoe; Robert Pijnenborg; Ivo A Brosens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-10
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  200     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  615.e1-6     Citation Subset:  AIM; IM    
Affiliation:
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom. j.brosens@imperial.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Endometrial Neoplasms / etiology
Endometriosis / etiology
Female
Humans
Menstruation / physiology*
Placentation / physiology
Pre-Eclampsia / etiology
Pregnancy / physiology*
Uterus / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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