| A role for menstruation in preconditioning the uterus for successful pregnancy. | |
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MedLine Citation:
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PMID: 19136085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Menstruation is widely viewed as serving no purpose other than to reinitiate the endometrial cycle in the absence of pregnancy. Yet, it is striking that cyclic endometrial decidualization followed by menstrual shedding is confined to the few species, including human beings, where placenta formation entails deep trophoblast invasion of maternal tissues and its vasculature. Both menstruation and pregnancy are inflammatory conditions that cause a degree of physiological ischemia-reperfusion tissue injury, albeit much more so in pregnancy. Thus, the emergence of cyclic menstruation may not have been an evolutionary coincidence but serves to protect uterine tissues from the profound hyperinflammation and oxidative stress associated with deep placentation, a process known as preconditioning. The concept of menstrual preconditioning provides a novel paradigm for understanding how reproductive disorders impact on pregnancy outcome. For example, endometriosis could be viewed as a disorder of exaggerated menstrual preconditioning that confers protection against placentation-related disorders, such as preeclampsia. |
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Authors:
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Jan J Brosens; Malcolm G Parker; Angus McIndoe; Robert Pijnenborg; Ivo A Brosens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-10 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 200 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 615.e1-6 Citation Subset: AIM; IM |
Affiliation:
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Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom. j.brosens@imperial.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Endometrial Neoplasms
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etiology Endometriosis / etiology Female Humans Menstruation / physiology* Placentation / physiology Pre-Eclampsia / etiology Pregnancy / physiology* Uterus / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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