Document Detail

The role and mechanism of fatty acids in gallstones.
MedLine Citation:
PMID:  17690037     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cholelithiasis is a common entity in China, but its etiology and pathogenesis have not been fully elucidated. Pigment stones of the intrahepatic and extrahepatic bile duct still form a high proportion in China, while they are rare in Europeans. To date, reports on fatty acids in stones remain few. We analyzed the quantity of fatty acids in different stones from Chinese and Japanese cases and discussed the role and mechanism of fatty acids in the formation of pigment stones. METHODS: Clinical data from 18 Chinese and 37 Japanese patients with different types of stones were analyzed using the procedure for extracting fatty acids from gallstones and high performance liquid chromatography. RESULTS: The total fatty acid and free fatty acid contents of pigment stones were markedly higher than those in black or cholesterol stones. The ratio of free saturated to free unsaturated fatty acids was highest in intrahepatic and less in extrahepatic pigment stones, which were significantly different from the other two kinds of stones. CONCLUSIONS: This indicates that phospholipase participates in the course of pigment stone formation. The action of phospholipase A1 is more important than phospholipase A2.
Shuo-Dong Wu; Kazuhisa Uchiyama; Ying Fan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepatobiliary & pancreatic diseases international : HBPD INT     Volume:  6     ISSN:  1499-3872     ISO Abbreviation:  HBPD INT     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101151457     Medline TA:  Hepatobiliary Pancreat Dis Int     Country:  China    
Other Details:
Languages:  eng     Pagination:  399-401     Citation Subset:  IM    
Department of General Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, China.
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MeSH Terms
Cholesterol / metabolism
Chromatography, High Pressure Liquid / methods
Fatty Acids / metabolism*
Gallstones / ethnology*,  metabolism*
Lauric Acids / metabolism
Liver / metabolism
Models, Biological
Phospholipases A1 / metabolism
Phospholipases A2 / metabolism
Stearic Acids / metabolism
Reg. No./Substance:
0/Fatty Acids; 0/Lauric Acids; 0/Stearic Acids; 143-07-7/lauric acid; 57-11-4/stearic acid; 57-88-5/Cholesterol; EC A1; EC A2

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