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The role of matrix metalloproteinases in acute coronary syndromes.
MedLine Citation:
PMID:  17822657     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Matrix metalloproteinases (MMPs) are an expanding group of proteolytic enzymes that participate in numerous physiological and pathological processes including embryogenesis, connective tissue turn-over, healing, angiogenesis, etc. Disturbances in matrixin activity are observed in carcinogenesis, some degenerative processes, and in inflammation, including atherogenesis. The role of matrixins in the pathology of the cardiovascular system seems to be particularly important in two processes: (1) atherosclerotic plaque development and rupture (leading to an acute coronary event) and (2) post-infarction remodeling of myocardium, leading to heart failure. The purpose of this paper is to gather and summarize information about the role of MMPs in acute coronary syndromes (ACS), in both the processes leading to coronary artery occlusion and the "myocardial consequence" of this event. In addition, some benefits and disadvantages of pharmacological intervention into this enzymatic network will be addressed.
Authors:
Jozefa Dabek; Andrzej Kulach; Zbigniew Gasior
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Publication Detail:
Type:  Journal Article     Date:  2007-06-29
Journal Detail:
Title:  European journal of internal medicine     Volume:  18     ISSN:  0953-6205     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  463-6     Citation Subset:  -    
Affiliation:
Department of Cardiology, Medical University of Silesia, Ziolowa 47, 40-635 Katowice, Poland.
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