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The role of maternal thyroid stimulating hormone receptor blocking antibodies in the etiology of congenital hypothyroidism in isfahan, iran.
MedLine Citation:
PMID:  22347610     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Considering the role of maternal thyroid stimulating hormone (TSH) receptor blocking antibody (TRAb) in the etiology of congenital hypothyroidism (CH), this study aimed to determine TRAb among patients with CH in Isfahan, Iran.
METHODS: In this case-control study, patients with CH and their mothers were compared with a group of healthy neonates and their mothers. Venous blood samples were obtained for measurement of TRAb using enzyme-linked immunosorbent assay (ELISA) method among mothers and their neonates. TSH of mothers was also determined.
RESULTS: The case group consisted of 65 patients with CH and their mothers; controls were 148 healthy neonates and their mothers. The prevalence of positive TRAb in patients with CH and their mothers was higher than in the control group (81.5% vs. 1.3% in mothers and 80% vs. 0% in neonates, respectively, P<0.05). The relationship between the TRAb and occurrence of CH was significant (P<0.05), whereas the corresponding figure was not significant for TRAb and the level of maternal and neonatal TSH in case and control groups (P>0.05).
CONCLUSION: It seems that autoimmunity has an important role in the etiology of CH. Further studies are necessary to determine other autoantibodies in CH patients.
Mahin Hashemipour; Shima Salehi Abari; Neda Mostofizadeh; Shaghayegh Haghjooy-Javanmard; Nafiseh Esmail; Silva Hovsepian; Amini Masoud; Roya Kelishadi; Akbar Hasanzadeh; Mehrdad Mirouliaei
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of preventive medicine     Volume:  3     ISSN:  2008-8213     ISO Abbreviation:  Int J Prev Med     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101535380     Medline TA:  Int J Prev Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  128-33     Citation Subset:  -    
Department of Pediatric Endocrinology, Endocrine and Metabolism Research Center and Child Health Promotion Research Center, Isfahan University of Medical Sciences (IUMS), Isfahan, Iran.
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