| The role of magnetoencephalography in "nonlesional" epilepsy. | |
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MedLine Citation:
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PMID: 21732934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The surgical management of neocortical epilepsy is challenging because many patients are without obvious structural lesions, or lesions are small and easily overlooked during routine clinical interpretation of magnetic resonance imaging (MRI) data. Even when functional imaging data suggest focal epileptiform pathology, in the absence of a concordant structural lesion, invasive monitoring is often required to confirm that an appropriate surgical target has been identified. This study sought to determine the extent to which knowledge of magnetoencephalography (MEG) data can augment the MRI-based detection of structural brain lesions. MRI and whole-head MEG data were obtained from 40 patients with neocortical epilepsy. As a result of MEG data, 29 cases were sent for MRI reevaluation. In seven of these cases, MEG-guided review led to specification of now clear, but previously unidentified, lesions. There were two additional cases for which follow-up high-resolution imaging did not confirm structural abnormalities. In patients with neocortical epilepsy, MEG is a useful adjunct to MRI for the identification of structural lesions. |
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Authors:
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Michael E Funke; Kevin Moore; William W Orrison; Jeffrey David Lewine |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epilepsia Volume: 52 Suppl 4 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-07 Completed Date: 2011-09-13 Revised Date: 2012-05-16 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 10-4 Citation Subset: IM |
Copyright Information:
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Wiley Periodicals, Inc. © 2011 International League Against Epilepsy. |
Affiliation:
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Department of Neurology, School of Medicine, University of Utah, Salt Lake City, Utah 84108, USA. michael.funke@hsc.utah.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain / pathology*, physiopathology Child Child, Preschool Electroencephalography Epilepsy / diagnosis, pathology*, physiopathology Female Humans Magnetoencephalography* Male Middle Aged Seizures / diagnosis, pathology, physiopathology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD051747/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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