Document Detail

The role of magnetic stimulation as a quantifier of motor disability in patients with multiple sclerosis.
MedLine Citation:
PMID:  1779236     Owner:  NLM     Status:  MEDLINE    
Magnetic stimulation was used to measure motor conduction time (MCT) between head and neck in a prospective longitudinal study of patients with multiple sclerosis (MS) and normal subjects. MCT measurements showed a high degree of reproducibility in normal subjects and patients with stable MS. In patients with definite MS, there was significant positive correlation between MCT and motor disability. In patients treated with steroids for relapse of MS, there was significant shortening of MCT following treatment in those who clinically improved, but not in those who were clinically unchanged. In a smaller group of patients followed for 3 months, MCT changes tended to mirror the clinical pattern. Magnetic stimulation should prove a useful tool for the quantification of motor disability, and monitoring the response to new treatments in MS.
R H Kandler; J A Jarratt; G A Davies-Jones; E J Gumpert; G S Venables; H J Sagar; A Zeman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  106     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
Department of Clinical Neurophysiology, Royal Hallamshire Hospital, Sheffield, U.K.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Arm / innervation
Magnetics / diagnostic use*
Middle Aged
Motor Neurons / physiology*
Multiple Sclerosis / drug therapy,  physiopathology*
Neck / innervation
Neural Conduction*
Prospective Studies
Reproducibility of Results
Reg. No./Substance:
0/Adrenal Cortex Hormones

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