Document Detail


The role of the mTOR pathway in regulating food intake.
MedLine Citation:
PMID:  20812152     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
mTOR is a principal effector of nutrient action, integrating nutritional inputs from glucose, amino acids and fatty acids, as well as growth factor and hormonal signals. The mTOR signaling pathway plays a vital role in regulating cell growth and proliferation, and has been studied extensively in a variety of metabolic and cancer models. However, only recently has the mTOR signaling pathway become implicated in the regulation of food intake. This review focuses on recent studies describing the role of hypothalamic and gastric mTOR signaling in suppressing food intake, and discusses the potential mechanisms through which this regulation occurs.
Authors:
Brian M Wiczer; George Thomas
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in drug discovery & development     Volume:  13     ISSN:  2040-3437     ISO Abbreviation:  Curr Opin Drug Discov Devel     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887519     Medline TA:  Curr Opin Drug Discov Devel     Country:  England    
Other Details:
Languages:  eng     Pagination:  604-12     Citation Subset:  IM    
Affiliation:
University of Cincinnati, Department of Cancer and Cell Biology, Metabolic Diseases Institute, College of Medicine, 2180 East Galbraith Road, Building D/Room 284, Cincinnati, OH 45237, USA. wiczerbn@ucmail.uc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anorexia / metabolism
Appetite Regulation / physiology*
Humans
Hypothalamus / metabolism
Nutritional Status / physiology*
Obesity / metabolism
Signal Transduction*
Stomach / metabolism
TOR Serine-Threonine Kinases / metabolism*,  physiology*
Chemical
Reg. No./Substance:
EC 2.7.1.1/TOR Serine-Threonine Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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