Document Detail

The role of lymphatic vessels in the heart.
MedLine Citation:
PMID:  19942415     Owner:  NLM     Status:  In-Data-Review    
Although cardiac lymphatic vessels have been described for over three centuries, research progress on the role of cardiac lymphatic vessels in regulating cardiac physiology and their disturbances in the pathogenesis of cardiac disease has progressed very slowly, largely due to technical challenges in developing both animal models and cardiac lymphatic vascular imaging technologies. This review summarizes evidence showing that blocking cardiac lymph flow may contribute to several forms of cardiac injury including cardiac lymphedema, cardiac valvular deformation, coronary arterial injury, conduction disturbances, myocardial injury, and poor heart performance in animal and human heart studies. Conversely, improving cardiac lymph flow may have beneficial effects on heart function after heart attack (myocardial infarction). In addition, this review summarizes recent hypotheses about the forces generating cardiac lymph flow, in which the role of both the subepicardial and mid-myocardial myocytes synchronized contractions causing lymph flow is discussed. Lastly, possible mechanisms of blood vessel injury caused by the failure of perivascular lymphatic remodeling are discussed.
Yingjie Cui
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Publication Detail:
Type:  Journal Article     Date:  2009-11-25
Journal Detail:
Title:  Pathophysiology : the official journal of the International Society for Pathophysiology / ISP     Volume:  17     ISSN:  0928-4680     ISO Abbreviation:  Pathophysiology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433813     Medline TA:  Pathophysiology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  307-14     Citation Subset:  -    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106-7290, United States; University Hospitals Harrington-McLaughlin Heart & Vascular Institute, University Hospitals Case Medical Center, WRB 4-537, 2103 Cornell Road, Cleveland, OH 44106-7290, United States.
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