Document Detail

The role of the lymphatic system in coronary atherosclerosis.
MedLine Citation:
PMID:  1569904     Owner:  NLM     Status:  MEDLINE    
Arguments are presented to support the hypothesis that the integrity of the coronary lymphatic system is an important factor in the development of coronary atherosclerosis. It is proposed that the lymphatic drainage of the epicardial coronary arteries is genetically inadequate, and that the flow of lymph from the heart is further impaired by gravitational factors due to man's upright position. Arguments are presented to support the concept that the intramural coronary arteries are protected from atherosclerosis because of a highly effective pericoronary lymphatic and venous capillary system and that the internal thoracic (internal mammary) artery is similarly protected from atherosclerosis because of its close relationship to an extensive lymphatic chain. It is proposed that the failure of the cardiac lymphatic system in the allogenic transplanted heart is a cause of the accelerated atherosclerosis in both epicardial and intramural coronary arteries.
A J Miller; A DeBoer; A Palmer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical hypotheses     Volume:  37     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-05-27     Completed Date:  1992-05-27     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM; S    
Department of Medicine, Northwestern Memorial Hospital, Chicago, IL 60611.
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MeSH Terms
Coronary Artery Disease / etiology*,  physiopathology
Coronary Vessels / physiopathology
Lymphatic System / physiopathology*
Models, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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