Document Detail

The role of lymphadenectomy in renal cell carcinoma.
MedLine Citation:
PMID:  19571759     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To critically appraise the current literature on the benefits of lymphadenectomy in patients with renal cell carcinoma. Many questions exist including: What is a 'standard' versus 'extended' lymph node dissection (LND)? What is the morbidity of a LND? What type of patient may derive the most benefit from LND? On the basis of preoperative staging, what is the benefit (therapeutic versus staging) for an individual patient? How does the performance of a LND impact current and future adjuvant and neoadjuvant studies? RECENT FINDINGS: Results from the EORTC 30881 trial did not show a therapeutic benefit to performing a 'standard' LND in patients with renal cell carcinoma, but the population predominantly comprised patients at the lowest risk of harboring lymph node metastasis. There are no prospective randomized trials with sufficient statistical power to analyze the therapeutic or staging effects in high-risk patients. SUMMARY: This review provides a synopsis of the available data regarding the therapeutic and staging benefits of lympadenectomy in the setting of renal cell carcinoma and should assist the urologist in educating affected patients as well as providing the urologist with the current evidenced-based data regarding this longstanding unanswered question.
Scott E Delacroix; Christopher G Wood
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in urology     Volume:  19     ISSN:  1473-6586     ISO Abbreviation:  Curr Opin Urol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200621     Medline TA:  Curr Opin Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-72     Citation Subset:  IM    
Department of Urology, Unit 1373, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
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MeSH Terms
Carcinoma, Renal Cell / surgery*
Evidence-Based Medicine
Kidney Neoplasms / surgery*
Lymph Node Excision* / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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