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The role of lung inflation and sodium transport in airway liquid clearance during lung aeration in newborn rabbits.
MedLine Citation:
PMID:  23269118     Owner:  NLM     Status:  Publisher    
Background:Recent phase contrast (PC) X-ray imaging studies suggest that inspiration primarily drives lung aeration and airway liquid clearance at birth, which questions the role of adrenaline-induced activation of epithelial sodium channels (ENaCs). We hypothesised that pressures generated by inspiration have a greater role in airway liquid clearance than ENaCs after birth.Methods:Rabbit pups (30 days of gestation) were delivered and sedated and 0.1ml of saline (S) or amiloride (Am; ENaC inhibitor) was instilled into the lungs before mechanical ventilation. Two other groups (30 days of gestation) were treated similarly, but were also given adrenaline (S/Ad and Am/Ad) before mechanical ventilation.Results:Amiloride and adrenaline did not affect functional residual capacity (FRC) recruitment (p>0.05). Amiloride increased the rate of FRC loss between inflations (Am: -5.2 ± 0.6ml/kg/s) whereas adrenaline reduced the rate of FRC loss (S/Ad: -1.9 ± 0.3ml/kg/s), compared to saline-treated controls (S: -3.5 ± -0.6ml/kg/s, p<0.05).Conclusion:These data indicate that inspiration is a major determinant of airway liquid clearance and FRC development during positive pressure ventilation. Although ENaC inhibition and adrenaline administration had no detectable effect on FRC development, ENaC may help to prevent liquid re-entering the airways during expiration.Pediatric Research (2012); doi:10.1038/pr.2012.197.
Melissa L Siew; Megan J Wallace; Beth J Allison; Marcus J Kitchen; Arjan B Te Pas; M Sirajul Islam; Robert A Lewis; Andreas Fouras; Naoto Yagi; Kentaro Uesugi; Stuart B Hooper
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-26
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Australia, 3800.
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