Document Detail


The role of lung function in brain tissue oxygenation following traumatic brain injury.
MedLine Citation:
PMID:  18173311     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Previous studies have demonstrated that periods of low brain tissue oxygen tension (PbtO2) are associated with poor outcome after head trauma but have primarily focused on cerebral and hemodynamic factors as causes of low PbtO2. The purpose of this study was to investigate the influence of lung function on PbtO2 with an oxygen challenge (increase in fraction of inspired oxygen [FiO2] concentration to 1.0). METHODS: This prospective observational cohort study was performed in the neurointensive care unit of the Level 1 trauma center at San Francisco General Hospital. Thirty-seven patients with severe traumatic brain injury (TBI) undergoing brain tissue oxygen monitoring as part of regular care underwent an oxygen challenge, consisting of an increase in FiO2 concentration from baseline to 1.0 for 20 minutes. Partial pressure of arterial oxygen (PaO2), PbtO2, and the ratio of PaO2 to FiO2 (the PF ratio) were determined before and after oxygen challenge. RESULTS: Patients with higher PF ratios achieved greater PbtO2 during oxygen challenge than those with a low PF ratio because they achieved a higher PaO2 after an oxygen challenge. Lung function, specifically the PF ratio, is a major determinant of the maximal PbtO2 attained during an oxygen challenge. CONCLUSIONS: Given that patients with TBI are at risk for pulmonary complications such as pneumonia, severe atelectasis, and adult respiratory distress syndrome, lung function must be considered when interpreting brain tissue oxygenation.
Authors:
Guy Rosenthal; J Claude Hemphill; Marco Sorani; Christine Martin; Diane Morabito; Michele Meeker; Vincent Wang; Geoffrey T Manley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  108     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-04     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurosurgery, University of California, San Francisco, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Gas Analysis
Brain / metabolism
Brain Injuries / metabolism*,  physiopathology*,  therapy
Cohort Studies
Female
Humans
Intracranial Pressure / physiology
Lung / physiopathology*
Male
Middle Aged
Oxygen Consumption / physiology*
Oxygen Inhalation Therapy
Grant Support
ID/Acronym/Agency:
R49-CCR903697//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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