| The role of liquid simethicone in enhancing endoscopic visibility prior to esophagogastroduodenoscopy (EGD): A prospective, randomized, double-blinded, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 20718163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Simethicone improves endoscopic visibility and diagnostic accuracy during colonoscopy and capsule endoscopy. Nevertheless, there have been limited data on its usefulness in esophagogastroduodenoscopy (EGD). OBJECTIVE: To evaluate the effectiveness of simethicone on enhancing endoscopic visibility in patients undergoing EGD. MATERIAL AND METHOD: 121 patients were randomized to take 2 ml ofeither liquid simethicone or placebo in 60 ml of water at 15-30 minutes before EGD. The severity scores of foam and bubbles at the esophagus, stomach and duodenum were compared. RESULTS: Simethicone improved endoscopic visibility by diminishing mean cumulative (6.83 +/- 2.4 vs. 11.05 +/- 2.6, p < 0.001) and local scores offoam and bubbles at all areas, and decreased the number and timing ofadjunctive simethicone washing (17.5% vs. 74.1%, p < 0.001 and 0 vs. 19 seconds, p < 0.001). Simethicone increased endoscopist and patient satisfaction significantly without having adverse effects. CONCLUSION: Using simethicone before EGD enhances endoscopic visibility, reduces adjunctive simethicone washing and increases endoscopist and patient satisfaction. |
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Authors:
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Suriya Keeratichananont; Abhasnee Sobhonslidsuk; Taya Kitiyakara; Narin Achalanan; Supamai Soonthornpun |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 93 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-09-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: 892-7 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antifoaming Agents / administration & dosage* Capsule Endoscopes* Double-Blind Method Endoscopy, Digestive System / methods* Female Humans Irrigation / methods* Male Middle Aged Patient Satisfaction Prospective Studies Simethicone / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Antifoaming Agents; 8050-81-5/Simethicone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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