Document Detail

The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart.
MedLine Citation:
PMID:  7181828     Owner:  NLM     Status:  MEDLINE    
A working hypothesis on pathogenesis of ischemic heart damage has been proposed. According to this hypothesis, a crucial role in conversion of reversible damage into irreversible damage is played by cardiomyocyte membrane destruction caused by the so-called "lipid triad". The latter comprises activation of lipid peroxidation, activation of phospholipases, and the detergentlike action of excessive amounts of free fatty acids and lysophospholipids. Marked activation of lipid peroxidation in experimental myocardial infarction, as well as reoxygenation following transitory ischemia, have been demonstrated. The proposed hypothesis and experimental data underly successful application of synthetic free radical scavengers (antioxidants) for heart protection against experimental myocardial infarction, transitory ischemia, and emotional, painful stress.
F Z Meerson; V E Kagan; Kozlov YuP; L M Belkina; Arkhipenko YuV
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  77     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1982 Sep-Oct
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  465-85     Citation Subset:  IM    
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MeSH Terms
Antioxidants / administration & dosage,  pharmacology*
Enzyme Activation
Lipid Peroxides / physiology*
Models, Biological
Myocardial Infarction / etiology*,  physiopathology,  prevention & control
Myocardium / metabolism
Phospholipases / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Lipid Peroxides; EC 3.1.-/Phospholipases

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