| On the role of lateral stabilization during early patterning in the pancreas. | |
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MedLine Citation:
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PMID: 23193107 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The cell fate decision of multi-potent pancreatic progenitor cells between the exocrine and endocrine lineages is regulated by Notch signalling, mediated by cell-cell interactions. However, canonical models of Notch-mediated lateral inhibition cannot explain the scattered spatial distribution of endocrine cells and the cell-type ratio in the developing pancreas. Based on evidence from acinar-to-islet cell transdifferentiation in vitro, we propose that lateral stabilization, i.e. positive feedback between adjacent progenitor cells, acts in parallel with lateral inhibition to regulate pattern formation in the pancreas. A simple mathematical model of transcriptional regulation and cell-cell interaction reveals the existence of multi-stability of spatial patterns whose simultaneous occurrence causes scattering of endocrine cells in the presence of noise. The scattering pattern allows for control of the endocrine-to-exocrine cell-type ratio by modulation of lateral stabilization strength. These theoretical results suggest a previously unrecognized role for lateral stabilization in lineage specification, spatial patterning and cell-type ratio control in organ development. |
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Authors:
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Walter de Back; Joseph Xu Zhou; Lutz Brusch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Royal Society, Interface / the Royal Society Volume: 10 ISSN: 1742-5662 ISO Abbreviation: J R Soc Interface Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2012-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101217269 Medline TA: J R Soc Interface Country: England |
Other Details:
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Languages: eng Pagination: 20120766 Citation Subset: IM |
Affiliation:
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Center for Information Services and High Performance Computing, Technische Universität Dresden, 01062 Dresden, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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