Document Detail

On the role of lateral stabilization during early patterning in the pancreas.
MedLine Citation:
PMID:  23193107     Owner:  NLM     Status:  MEDLINE    
The cell fate decision of multi-potent pancreatic progenitor cells between the exocrine and endocrine lineages is regulated by Notch signalling, mediated by cell-cell interactions. However, canonical models of Notch-mediated lateral inhibition cannot explain the scattered spatial distribution of endocrine cells and the cell-type ratio in the developing pancreas. Based on evidence from acinar-to-islet cell transdifferentiation in vitro, we propose that lateral stabilization, i.e. positive feedback between adjacent progenitor cells, acts in parallel with lateral inhibition to regulate pattern formation in the pancreas. A simple mathematical model of transcriptional regulation and cell-cell interaction reveals the existence of multi-stability of spatial patterns whose simultaneous occurrence causes scattering of endocrine cells in the presence of noise. The scattering pattern allows for control of the endocrine-to-exocrine cell-type ratio by modulation of lateral stabilization strength. These theoretical results suggest a previously unrecognized role for lateral stabilization in lineage specification, spatial patterning and cell-type ratio control in organ development.
Walter de Back; Joseph Xu Zhou; Lutz Brusch
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Royal Society, Interface / the Royal Society     Volume:  10     ISSN:  1742-5662     ISO Abbreviation:  J R Soc Interface     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-05-01     Revised Date:  2014-02-14    
Medline Journal Info:
Nlm Unique ID:  101217269     Medline TA:  J R Soc Interface     Country:  England    
Other Details:
Languages:  eng     Pagination:  20120766     Citation Subset:  IM    
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MeSH Terms
Acinar Cells / cytology
Cell Communication / physiology*
Cell Differentiation / physiology*
Gene Expression Regulation / physiology*
Islets of Langerhans / cytology
Models, Biological
Morphogenesis / physiology*
Multipotent Stem Cells / physiology*
Pancreas / cytology,  embryology*
Receptors, Notch / metabolism
Signal Transduction / physiology
Reg. No./Substance:
0/Receptors, Notch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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