| The role of lactate in the exercise-induced human growth hormone response: evidence from McArdle disease. | |
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MedLine Citation:
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PMID: 18184755 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: Increased blood lactate concentration has been suggested as a primary stimulus for the exercise-induced growth hormone response (EIGR). Patients with McArdle disease are unable to produce lactate in response to exercise and thus offer a unique model to assess the role of lactate in the EIGR. Accordingly, McArdle's patients were exercised to test the hypothesis that lactate is a major stimulus of the EIGR. METHODS: 11 patients with McArdle disease (3 male, 8 female; age: 35.5 (SD 13.9) years, height: 166 (8) cm, body mass: 75.2 (13.1) kg) were recruited for the study. The patients walked initially at 0.42 m/s, increasing by 0.14 m/s per 3 min stage. Exercise was terminated when participants completed 3 minutes at 1.80 m/s or when a Borg CR10 pain scale rating of "4" was reached. Stages were separated by 60 s for capillary blood sampling for analysis of hGH and blood lactate concentration. RESULTS: McArdle's patients' blood lactate levels remained at resting levels (0.3-1.2 mmol/l) as exercise intensity increased. Nine out of 11 participants failed to demonstrate an EIGR obtaining hGH values below the clinical definition of a response (>3 microg/l). CONCLUSION: The absence of an EIGR in nine out of 11 participants suggests that lactate could play a major role in the EIGR in humans. |
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Authors:
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R J Godfrey; G P Whyte; J Buckley; R Quinlivan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-09 |
Journal Detail:
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Title: British journal of sports medicine Volume: 43 ISSN: 1473-0480 ISO Abbreviation: Br J Sports Med Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0432520 Medline TA: Br J Sports Med Country: England |
Other Details:
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Languages: eng Pagination: 521-5 Citation Subset: IM |
Affiliation:
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Centre for Sports Medicine and Human Performance, School of Sport and Education, Brunel University, Uxbridge, UB8 3PH, United Kingdom. richard.godfrey@brunel.ac.uk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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