Document Detail


The role of kynurenines in the pathomechanism of amyotrophic lateral sclerosis and multiple sclerosis: therapeutic implications.
MedLine Citation:
PMID:  22258797     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tryptophan is one of the essential amino acids, 80% of which is catabolised in the extrahepatic tissues by indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme of the kynurenine pathway. Metabolites along the kynurenine pathway have been implicated to play a role in the pathomechanism of neuroinflammatory and neurodegenerative disorders. Changes in the concentration levels of kynurenines can shift the balance to pathological conditions. The ability to influence the metabolism towards the neuroprotective branch of the kynurenine pathway, i.e. towards kynurenic acid (KYNA) synthesis, may be one option in preventing neurodegenerative diseases. Three potential therapeutic strategies could be feasible to develop drugs to live up to expectations: (1) chemically related drugs with better bioavailability and higher affinity to the binding sites of excitatory receptors; (2) prodrugs of KYNA, which easily cross the blood-brain barrier combined with an inhibitor of organic acid transport for enhancement of the brain KYNA concentration; (3) inhibitors of enzymes of the kynurenine pathway. In this review, we focus on aspects of the pathomechanism and therapeutic possibilities of amyotrophic lateral sclerosis and multiple sclerosis that may be influenced by kynurenines.
Authors:
Judit Füvesi; Cecilia Rajda; Krisztina Bencsik; József Toldi; László Vécsei
Related Documents :
21123067 - Glycosylated nordihydroguaiaretic acids as anti-cancer agents.
21295367 - Effect of acid tolerance response (atr) on attachment of listeria monocytogenes scott a...
7769267 - Polyunsaturated fatty acid enrichment increases ultraviolet a-induced lipid peroxidatio...
16464127 - High-light-induced changes on photosynthesis, pigments, sugars, lipids and antioxidant ...
3532107 - Structural evidence that endothelial cell growth factor beta is the precursor of both e...
9648217 - Isolation of agrobacterium sp. strain knk712 that produces n-carbamyl-d-amino acid amid...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-19
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  -     ISSN:  1435-1463     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, Szeged, 6725, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Modulation of in vivo GABA-evoked responses by nitric oxide-active compounds in the globus pallidus ...
Next Document:  Dynamic cultural modulation of neural responses to one's own and friend's faces.