Document Detail

A role for kisspeptins in pregnancy: facts and speculations.
MedLine Citation:
PMID:  19336473     Owner:  NLM     Status:  In-Process    
Kisspeptin is a neuropeptide that was originally discovered in 1996 from a metastasis tumour suppressor gene, KISS1 and was appropriately named metastin. More recently, the discovery of inactivating mutations in the receptor for kisspeptin, a G protein-coupled receptor, GPR54 (KISS1R), have been shown to result in a failure to progress through puberty in man. These findings have led to the kisspeptin/KISS1R system being described as an essential gatekeeper of reproductive function. Recent studies have suggested additional roles of kisspeptin, other than in the central control of the gonadotropic axis including placentation and pregnancy, energy homeostasis and cardiovascular function. Therefore, kisspeptin-KISS1R signalling potentially plays diverse roles in human physiology. Here, we review the literature regarding the role and physiological significance of kisspeptin in pregnancy and highlight some of the key questions that require addressing.
Rebecca M Reynolds; James J Logie; Antonia K Roseweir; Angus J McKnight; Robert P Millar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-31
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  138     ISSN:  1741-7899     ISO Abbreviation:  Reproduction     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Endocrinology Unit, Centre for Cardiovascular Sciences, Jennifer Brown Research Laboratory, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
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//Medical Research Council

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