Document Detail


The role of kinins in the antihypertensive and cardioprotective effects of ACE inhibitors.
MedLine Citation:
PMID:  9429842     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Kinins are highly potent vasoactive peptides. They reduce blood pressure by vasodilation and are cardio- and vasoprotective. ACE inhibitors potentiate the actions of endogenous kinins by about 50-fold. Kinins are involved in the blood pressure-lowering effects of ACE inhibitors in all forms of hypertension associated with stimulation of the renin-angiotensin system. In addition, kinins play an important role in the metabolic, and cardio- and vasoprotective effects of ACE inhibitors.
Authors:
G Bönner
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  54 Suppl 5     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1997  
Date Detail:
Created Date:  1998-02-11     Completed Date:  1998-02-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
Affiliation:
Clinic Lazariterhof, Centre for Medical Rehabilitation, Bad Krozingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / adverse effects,  pharmacology*
Animals
Antihypertensive Agents / pharmacology*
Blood Glucose / metabolism
Blood Pressure / drug effects
Bradykinin / administration & dosage,  pharmacology
Disease Models, Animal
Humans
Kinins / physiology*
Renin-Angiotensin System / drug effects
Reperfusion Injury / prevention & control
Vascular Resistance / drug effects
Vasodilation / drug effects
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Blood Glucose; 0/Kinins; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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