| The role of kinins in the antihypertensive and cardioprotective effects of ACE inhibitors. | |
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MedLine Citation:
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PMID: 9429842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kinins are highly potent vasoactive peptides. They reduce blood pressure by vasodilation and are cardio- and vasoprotective. ACE inhibitors potentiate the actions of endogenous kinins by about 50-fold. Kinins are involved in the blood pressure-lowering effects of ACE inhibitors in all forms of hypertension associated with stimulation of the renin-angiotensin system. In addition, kinins play an important role in the metabolic, and cardio- and vasoprotective effects of ACE inhibitors. |
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Authors:
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G Bönner |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Drugs Volume: 54 Suppl 5 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 1997 |
Date Detail:
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Created Date: 1998-02-11 Completed Date: 1998-02-11 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 23-30 Citation Subset: IM |
Affiliation:
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Clinic Lazariterhof, Centre for Medical Rehabilitation, Bad Krozingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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adverse effects,
pharmacology* Animals Antihypertensive Agents / pharmacology* Blood Glucose / metabolism Blood Pressure / drug effects Bradykinin / administration & dosage, pharmacology Disease Models, Animal Humans Kinins / physiology* Renin-Angiotensin System / drug effects Reperfusion Injury / prevention & control Vascular Resistance / drug effects Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Blood Glucose; 0/Kinins; 58-82-2/Bradykinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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