Document Detail

The role of the irritative zone and of the number and distribution of calcifications in the severity of epilepsy associated with intracranial calcifications.
MedLine Citation:
PMID:  17220993     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the influence of the location of the irritative zone, and the number and the distribution of the intracranial calcifications in the severity of epilepsy associated with intracranial calcifications. METHOD: We studied 47 patients with epilepsy and intracranial calcifications, 24 with normal (Group A) and 23 with abnormal interictal EEGs (Group B), a control group (n=21) with abnormal interictal EEGs and normal CT-scans (Group C). Clinical, electroencephalographic and neuroradiological features were compared among groups. RESULTS: Temporal lobe interictal EEG abnormalities were found in 23/24 Group B patients, and in all Group C patients. Most Group B and Group C patients presented temporal lobe seizure symptomatology, whereas in most Group A patients symptomatology was rolandic (p=0.0001). Epilepsy was more severe in Group B and Group C patients than in Group A patients (p=0.0001 and p=0.0054). No relationship was found between the number of calcifications and epilepsy severity. CONCLUSION: An irritative zone at the temporal lobe is more relevant in determining the severity, symptomatology and frequency of seizures than the number and location of calcifications.
Pedro André Kowacs; Enio Rogacheski; Juliano Muzzio; Lineu César Werneck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  64     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2008-01-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  905-11     Citation Subset:  IM    
Neurology Division, Internal Medicine Department, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.
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MeSH Terms
Calcinosis / complications*,  pathology,  radiography
Case-Control Studies
Cerebral Cortex / radiography
Epilepsy / etiology*,  pathology,  radiography
Middle Aged
Neurocysticercosis / complications*,  pathology,  radiography
Severity of Illness Index
Tomography, X-Ray Computed
Erratum In:
Arq Neuropsiquiatr. 2007 Mar;65(1):182

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