Document Detail


The role of iron overload on oxidative stress in sickle cell anemia.
MedLine Citation:
PMID:  23227847     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Repeated blood transfusions in patients with sickle cell anemia (SCA) increases the risk of iron overload (IO), contributing to oxidative stress. Materials & methods: Blood samples of 15 SCA patients without IO (group 1) and 15 SCA patients with IO (group 2) and 30 healthy individuals were collected to investigate oxidative stress. IO was categorized using repeated measures of serum ferritin. The biomarkers evaluated were plasmatic malondialdehyde (MDA), nitrite and erythrocyte catalase. Results: MDA and nitrite were higher in group 2 than in group 1 and the healthy group (p < 0.001 for MDA and nitrite). Catalase presented lower in group 2 than group 1 and the healthy group (p < 0.001). We obtained a positive correlation between ferritin and MDA (r = 0.40; p < 0.02), and between ferritin and nitrite (r = 0359; p = 0.023). Conclusion: The results demonstrated that IO is an important risk factor for enhanced oxidative stress in SCA.
Authors:
Talyta Ellen de Jesus Dos Santos; Geane Félix de Sousa; Maritza Cavalcante Barbosa; Romélia Pinheiro Gonçalves
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers in medicine     Volume:  6     ISSN:  1752-0371     ISO Abbreviation:  Biomark Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312535     Medline TA:  Biomark Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  813-9     Citation Subset:  IM    
Affiliation:
Department of Clinical & Toxicological Analysis of Federal University of Ceara, Fortaleza, Ceara, Brazil.
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