Document Detail

The role of iron in the proliferation of Drosophila l(2) mbn cells.
MedLine Citation:
PMID:  20807501     Owner:  NLM     Status:  MEDLINE    
Iron is essential for life and is needed for cell proliferation and cell cycle progression. Iron deprivation results first in cell cycle arrest and then in apoptosis. The Drosophila tumorous larval hemocyte cell line l(2) mbn was used to study the sensitivity and cellular response to iron deprivation through the chelator desferrioxamine (DFO). At a concentration of 10 μM DFO or more the proliferation was inhibited reversibly, while the amount of dead cells did not increase. FACS analysis showed that the cell cycle was arrested in G1/S-phase and the transcript level of cycE was decreased to less than 50% of control cells. These results show that iron chelation in this insect tumorous cell line causes a specific and coordinated cell cycle arrest.
Christoph Metzendorf; Maria I Lind
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-31
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  400     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2010-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Comparative Physiology, Uppsala University, Norbyvägen 18A, SE-75236 Uppsala, Sweden.
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MeSH Terms
Cell Cycle*
Cell Line, Tumor
Cell Proliferation*
Drosophila melanogaster / cytology*,  drug effects,  genetics
Gene Expression Regulation
Iron / pharmacology,  physiology*
Reg. No./Substance:

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