| The role of iron in the immune response to bacterial infection. | |
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MedLine Citation:
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PMID: 21161695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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My laboratory has been interested for some time in the influence of iron, a nutrient that is essential for both microbial pathogens and their mammalian hosts, on the course of infectious disease. Our studies indicate that alterations in the expression of host molecules that sequester or transport iron can have direct effects on pathogen growth and can also have an impact on the ability to mount normal immune responses. We have elucidated the mechanistic basis for some of these observations, and have started to apply our findings in strategies to control abnormalities of inflammation and iron metabolism. I will review here what we have learned about the interactions between iron and immunity and discuss the implications of the information that we have acquired. |
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Authors:
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Bobby J Cherayil |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Immunologic research Volume: 50 ISSN: 1559-0755 ISO Abbreviation: Immunol. Res. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-08-11 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
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Mucosal Immunology Laboratory, MassGeneral Hospital for Children, Charlestown, MA 02129, USA. cherayil@helix.mgh.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Infections / immunology* Cation Transport Proteins / metabolism Communicable Diseases / immunology Gene Expression Regulation / immunology Homeostasis / immunology Humans Immunity / immunology* Inflammation / immunology Intracellular Space / immunology Iron / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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P30 DK040561-15/DK/NIDDK NIH HHS; R56 AI089700-01/AI/NIAID NIH HHS; R56AI089700/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cation Transport Proteins; 0/metal transporting protein 1; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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