Document Detail

A role for ion channels in glioma cell invasion.
MedLine Citation:
PMID:  16520829     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Many cells, including neuronal and glial progenitor cells, stem cells and microglial cells, have the capacity to move through the extracellular spaces of the developing and mature brain. This is particularly pronounced in astrocyte-derived tumors, gliomas, which diffusely infiltrate the normal brain. Although a significant body of literature exists regarding signals that are involved in the guidance of cells and their processes, little attention has been paid to cell-shape and cell-volume changes of migratory cells. However, extracellular spaces in the brain are very narrow and represent a major obstacle that requires cells to dynamically regulate their volume. Recent studies in glioma cells show that this involves the secretion of Cl(-) and K(+) with water. Pharmacological inhibition of Cl(-) channels impairs their ability to migrate and limits tumor progression in experimental tumor models. One Cl(-)-channel inhibitor, chlorotoxin, is currently in Phase II clinical trials to treat malignant glioma. This article reviews our current knowledge of cell-volume changes and the role of ion channels during the migration of glioma cells. It also discusses evidence that supports the importance of channel-mediated cell-volume changes in the migration of immature neurons and progenitor cells during development. New unpublished data is presented, which demonstrates that Cl(-) and K(+) channels involved in cell shrinkage localize to lipid-raft domains on the invadipodia of glioma cells and that their presence might be regulated by trafficking of these proteins in and out of lipid rafts.
Michael B McFerrin; Harald Sontheimer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuron glia biology     Volume:  2     ISSN:  1741-0533     ISO Abbreviation:  Neuron Glia Biol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2008-07-18     Completed Date:  2012-10-02     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  101217278     Medline TA:  Neuron Glia Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  39-49     Citation Subset:  -    
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Grant Support
P30 HD038985/HD/NICHD NIH HHS; P30 HD038985-05/HD/NICHD NIH HHS; P50 CA097247/CA/NCI NIH HHS; P50 CA097247-04/CA/NCI NIH HHS; R01 NS031234/NS/NINDS NIH HHS; R01 NS031234-13/NS/NINDS NIH HHS; R01 NS036692/NS/NINDS NIH HHS; R01 NS036692-08/NS/NINDS NIH HHS

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