Document Detail

The role of the invasive, placental trophoblast in human pregnancy.
MedLine Citation:
PMID:  22717871     Owner:  NLM     Status:  Publisher    
During early pregnancy the placenta-derived extravillous trophoblast starts to invade the maternal uterus in order to regulate adequate blood flow and nutrient supply to the growing fetus. A unique set of events including plugging and remodelling of maternal vessels, regulation of oxygen levels, as well as the crosstalk with maternal decidual cells are thought to be precisely controlled by the invading extravillous trophoblasts. However, defects in these processes can lead to severe complications during pregnancy threatening the well-being of both the mother and the developing fetus. For instance incomplete trophoblast-associated invasion and arterial remodelling are associated with preeclampsia, the most common pregnancy-related complication. Moreover, failure in proper placental development and adequate fetal nutrition could be effective later in life, as growth-restricted neonates have a higher risk to develop adult onset of hypertension, heart disease and diabetes mellitus. Consequently, a detailed understanding of the mechanisms that underlie trophoblast invasion is thought to improve both diagnosis and treatment of various pregnancy-related disorders.
Jürgen Pollheimer; Martin Knöfler
Publication Detail:
Journal Detail:
Title:  Wiener medizinische Wochenschrift (1946)     Volume:  162     ISSN:  1563-258X     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708475     Medline TA:  Wien Med Wochenschr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  187-190     Citation Subset:  -    
Reproductive Biology Unit, Department of Obstetrics and Fetal-Maternal Medicine, Medical University of Vienna, Vienna, Austria,
Vernacular Title:
Die Rolle des invasiven, plazentaren Trophoblasten in der Schwangerschaft.
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