| The role of intrarenal prostaglandins and angiotensin II in acute cyclosporine-induced vasoconstriction. | |
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MedLine Citation:
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PMID: 1858042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cyclosporine causes intrarenal vasoconstriction, which may account for its nephrotoxic effects. In this study we investigated the role of endogenous prostaglandins and angiotensin II in cyclosporine-induced intrarenal vasoconstriction. Split hydronephrotic kidneys in decerebrate rats (n = 16) were suspended in an environmentally controlled tissue bath. Interlobular, afferent, and efferent arteriolar diameters and red blood cell velocity were measured by in vivo video-microscopy and Doppler velocimetry. After topical application of cyclosporine to the kidney in the tissue bath, a 12% +/- 2% constriction of the interlobular and a 28% +/- 5% reduction in interlobular blood flow occurred. The afferent and efferent arterioles also constricted by 13% +/- 2% and 10% +/- 3%, respectively. Prostaglandin inhibition with mefenemate augmented this vasoconstriction (16% +/- 2% at interlobular and 21% +/- 4% at afferent arterioles) and reduction in interlobular blood flow (38% +/- 8%) below baseline values. Mefenemate alone resulted in a 35% +/- 5% reduction in interlobular blood flow, which was not further augmented by cyclosporine. In contrast, local competitive angiotensin II-receptor inhibition with saralasin maintained blood flow after cyclosporine and prevented intrarenal vasoconstriction by cyclosporine. This suggests that prostaglandins protect against intrarenal vasoconstriction and that acute cyclosporine-induced vasoconstriction is mediated through angiotensin II receptors. |
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Authors:
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J S Abraham; F R Bentley; R N Garrison |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Surgery Volume: 110 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-08-28 Completed Date: 1991-08-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 343-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Louisville School of Medicine, KY 40292. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Sarcosine-8-Isoleucine Angiotensin II
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pharmacology Angiotensin II / physiology* Animals Blood Flow Velocity / drug effects Cyclosporins / pharmacology* Hemodynamics / drug effects Kidney / blood supply* Male Mefenamic Acid / pharmacology Microcirculation / drug effects Prostaglandins / physiology* Rats Rats, Inbred Strains Receptors, Angiotensin / drug effects Time Factors Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Cyclosporins; 0/Prostaglandins; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 61-68-7/Mefenamic Acid; 9088-01-1/1-Sarcosine-8-Isoleucine Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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