Document Detail


The role of intraluminal tension and pH in the development of necrotizing enterocolitis: an animal model.
MedLine Citation:
PMID:  3559859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Presented is an in vivo animal model of necrotizing enterocolitis (NEC) in which we used an isolated loop of rabbit colon. Changes in mucosal perfusion and macroscopic and microscopic appearances were studied after exposure of the mucosa to different intraluminal tensions and pHs. Mucosal perfusion was reduced with increasing intraluminal tension and decreasing pH. Histologic changes consistent with NEC were identified after five hours when the mucosa had been exposed to both increased intraluminal tension and decreased pH. Factors affecting intraluminal tension and pH could influence the development of NEC in the neonate.
Authors:
W I Garstin; B D Kenny; D McAneaney; C C Patterson; V E Boston
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  22     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-05-19     Completed Date:  1987-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbohydrate Metabolism
Colon / blood supply,  metabolism,  pathology,  physiopathology*
Disease Models, Animal*
Enterocolitis, Pseudomembranous / metabolism,  pathology,  physiopathology*
Hydrogen / metabolism
Hydrogen-Ion Concentration
Intestinal Absorption
Intestinal Mucosa / blood supply,  pathology,  physiopathology
Pressure
Rabbits
Chemical
Reg. No./Substance:
1333-74-0/Hydrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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