| The role of intraluminal tension and pH in the development of necrotizing enterocolitis: an animal model. | |
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MedLine Citation:
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PMID: 3559859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Presented is an in vivo animal model of necrotizing enterocolitis (NEC) in which we used an isolated loop of rabbit colon. Changes in mucosal perfusion and macroscopic and microscopic appearances were studied after exposure of the mucosa to different intraluminal tensions and pHs. Mucosal perfusion was reduced with increasing intraluminal tension and decreasing pH. Histologic changes consistent with NEC were identified after five hours when the mucosa had been exposed to both increased intraluminal tension and decreased pH. Factors affecting intraluminal tension and pH could influence the development of NEC in the neonate. |
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Authors:
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W I Garstin; B D Kenny; D McAneaney; C C Patterson; V E Boston |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 22 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1987 Mar |
Date Detail:
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Created Date: 1987-05-19 Completed Date: 1987-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 205-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbohydrate Metabolism Colon / blood supply, metabolism, pathology, physiopathology* Disease Models, Animal* Enterocolitis, Pseudomembranous / metabolism, pathology, physiopathology* Hydrogen / metabolism Hydrogen-Ion Concentration Intestinal Absorption Intestinal Mucosa / blood supply, pathology, physiopathology Pressure Rabbits |
| Chemical | |
Reg. No./Substance:
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1333-74-0/Hydrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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