Document Detail


The role of interstitial stress in lymphatic function and lymphangiogenesis.
MedLine Citation:
PMID:  12543729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The management and control of tissue fluid balance depends on the highly regulated orchestration of various interstitial factors. In particular, lymphatic function, lymphatic biology, and development (lymphangiogenesis), and the extracellular matrix all contribute to interstitial fluid balance. In light of the dynamic interdependence of these factors, our lab has been working towards establishing a mechanical-molecular picture of the process of lymphangiogenesis-that is, bridging the physiological context of lymphangiogenesis with its molecular regulation by studying the coordination of mechanical forces, ECM development, lymphatic biology, and lymphatic capillary organization and development. Our working hypothesis is that the physiological driving force for lymphangiogenesis is the need for organized interstitial fluid flow. This paper will outline the rationale and background for such an approach and highlight some of the recently published findings of our lab and others that support this concept.
Authors:
Melody A Swartz; Kendrick C Boardman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  979     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-24     Completed Date:  2003-03-31     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-210; discussion 229-34     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA. m-swartz2@nothwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Endothelial Growth Factors / physiology
Humans
Intercellular Signaling Peptides and Proteins / physiology
Lymphatic Diseases / pathology,  physiopathology*
Lymphatic System / physiopathology*
Lymphokines / physiology
Models, Animal
Receptors, Vascular Endothelial Growth Factor / physiology
Stress, Mechanical
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Water-Electrolyte Balance / physiology
Chemical
Reg. No./Substance:
0/Endothelial Growth Factors; 0/Intercellular Signaling Peptides and Proteins; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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