Document Detail


The role of interstitial fluid pressurization in articular cartilage lubrication.
MedLine Citation:
PMID:  19464689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the last two decades, considerable progress has been reported in the field of cartilage mechanics that impacts our understanding of the role of interstitial fluid pressurization on cartilage lubrication. Theoretical and experimental studies have demonstrated that the interstitial fluid of cartilage pressurizes considerably under loading, potentially supporting most of the applied load under various transient or steady-state conditions. The fraction of the total load supported by fluid pressurization has been called the fluid load support. Experimental studies have demonstrated that the friction coefficient of cartilage correlates negatively with this variable, achieving remarkably low values when the fluid load support is greatest. A theoretical framework that embodies this relationship has been validated against experiments, predicting and explaining various outcomes, and demonstrating that a low friction coefficient can be maintained for prolonged loading durations under normal physiological function. This paper reviews salient aspects of this topic, as well as its implications for improving our understanding of boundary lubrication by molecular species in synovial fluid and the cartilage superficial zone. Effects of cartilage degeneration on its frictional response are also reviewed.
Authors:
Gerard A Ateshian
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-05-22
Journal Detail:
Title:  Journal of biomechanics     Volume:  42     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-09-21     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1163-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cartilage, Articular / physiology*
Chondroitin ABC Lyase / metabolism
Compressive Strength
Extracellular Fluid / physiology*
Friction / physiology*
Humans
Stress, Mechanical
Synovial Fluid / physiology
Grant Support
ID/Acronym/Agency:
AR 43628/AR/NIAMS NIH HHS; AR 46532/AR/NIAMS NIH HHS; R01 AR043628/AR/NIAMS NIH HHS; R01 AR043628-13/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
EC 4.2.2.20/Chondroitin ABC Lyase
Comments/Corrections

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