| The role of interleukin-6 in the formation of the coronary vasculature. | |
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MedLine Citation:
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PMID: 19709461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The formation and the patterning of the coronary vasculature are critical to the development and pathology of the heart. Alterations in cytokine signaling and biomechanical load can alter the vascular distribution of the vessels within the heart. Changes in the physical patterning of the vasculature can have significant impacts on the relationships of the pressure-flow network and distribution of critical growth and survival factors to the tissue. Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates several biological processes, including vasculogenesis. Using both immunohistological and cardioangiographic analyses, we tested the hypothesis that IL-6-loss will result in decreased vessel density, along with changes in vascular distribution. Moreover, given the impact of vascular patterning on pressure-flow and distribution mechanics, we utilized non-Euclidean geometrical fractal analysis to quantify the changes in patterning resulting from IL-6-loss. Our analyses revealed that IL-6-loss results in a decreased capillary density and increase in intercapillary distances, but does not alter vessel size or diameter. We also observed that the IL-6-/- coronary vasculature had a marked increase in fractal dimension (D value), indicating that IL-6-loss alters vascular patterning. Characterization of IL-6-loss on coronary vasculature may lend insight into the role of IL-6 in the formation and patterning of the vascular bed. |
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Authors:
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Indroneal Banerjee; John W Fuseler; Colby A Souders; Stephanie L K Bowers; Troy A Baudino |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-08-27 |
Journal Detail:
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Title: Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada Volume: 15 ISSN: 1435-8115 ISO Abbreviation: Microsc. Microanal. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-16 Completed Date: 2009-11-06 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9712707 Medline TA: Microsc Microanal Country: United States |
Other Details:
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Languages: eng Pagination: 415-21 Citation Subset: IM |
Affiliation:
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Cell and Developmental Biology and Anatomy, University of South Carolina School of Medicine, 6439 Garners Ferry Rd., Columbia, SC 29209, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiography Animals Coronary Vessels / growth & development* Immunohistochemistry Interleukin-6 / deficiency, physiology* Mice Mice, Inbred C57BL Mice, Knockout Neovascularization, Physiologic* |
| Grant Support | |
ID/Acronym/Agency:
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1R01 HL85847/HL/NHLBI NIH HHS; R01 HL085847-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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