Document Detail

The role of interferon-gamma in murine pneumococcal pneumonia.
MedLine Citation:
PMID:  11756986     Owner:  NLM     Status:  MEDLINE    
To determine the role of interferon (IFN)-gamma in pneumonia, IFN-gamma receptor-deficient (IFN-gamma R(-/-)) and 129/Sv (wild-type [wt]) mice were inoculated intranasally with Streptococcus pneumoniae. Although mortality did not differ between the groups 48 h after inoculation, IFN-gamma R(-/-) mice had significantly fewer pneumococci in their lungs than the wt mice. Similarly, IFN-gamma(-/-) mice had fewer colony-forming units in lungs than wt mice. The relatively increased resistance of IFN-gamma R(-/-) mice was not related to favorable effects on defense mechanisms known to contribute to antibacterial immunity-that is, the neutrophilic influx was reduced and the cytokine and nitric oxide levels were similar or lower in IFN-gamma R(-/-) mice. In contrast, mice treated with anti-IFN-gamma did not demonstrate a consistently altered bacterial outgrowth, compared with mice treated with a control antibody. These data suggest that endogenous IFN-gamma, despite its protective role in defense against intracellular pathogens, does not serve a protective role during pneumococcal pneumonia.
Anita W Rijneveld; Fanny N Lauw; Marc J Schultz; Sandrine Florquin; Anje A Te Velde; Peter Speelman; Sander J H Van Deventer; Tom Van Der Poll
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2001-12-14
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  185     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-01-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-7     Citation Subset:  AIM; IM    
Department of Experimental Internal Medicine, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
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MeSH Terms
Bronchoalveolar Lavage Fluid / cytology
Granulocytes / immunology
Immunity, Innate
Interferon-gamma / genetics,  metabolism*
Interleukin-12 / analysis
Interleukin-6 / analysis
Lung / immunology
Macrophage-1 Antigen / isolation & purification
Mice, Mutant Strains
Nitric Oxide / analysis
Pneumonia, Pneumococcal / etiology*,  immunology,  mortality
Receptors, Interferon / genetics,  metabolism*
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Interleukin-6; 0/Macrophage-1 Antigen; 0/Receptors, Interferon; 0/Tumor Necrosis Factor-alpha; 0/interferon gamma receptor; 10102-43-9/Nitric Oxide; 187348-17-0/Interleukin-12; 82115-62-6/Interferon-gamma

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