| The role of insulin receptor signaling in synaptic plasticity and cognitive function. | |
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MedLine Citation:
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PMID: 20438663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin is the most abundant peptidergic hormone secreted by the pancreatic islets of Langerhans and plays an important role in organic metabolism. In recent years, various functions for insulin receptor signaling in the brain have been suggested in normal neurophysiology, and a dysregulation of insulin secretion or insulin receptor signaling has been reported in serious mental illnesses. Several lines of work in both laboratory animals and humans suggest that when neurons in cognitive brain regions such as the hippocampus and cerebral cortex do not make enough insulin or cannot respond to insulin properly, everything from very mild memory loss to severe neurodegenerative diseases can result. On the other hand, administration of insulin exerts memory-enhancing action in both humans and experimental animals. Insulin has also recently been shown to regulate the endocytosis of 3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors, which causes long-term depression (LTD) of excitatory synaptic transmission. The fact that LTD in the mammalian brain is generally assumed to be a synaptic mechanism underlying learning during novel experiences, this insulin-induced LTD may therefore serve as an important role in brain information processing. Recent advances in the knowledge of the biological role of brain insulin receptor signaling in relation to synaptic plasticity and cognitive function, and of the regulatory signaling mechanisms involved in these processes will be discussed in the article. |
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Authors:
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Chiung-Chun Huang; Cheng-Che Lee; Kuei-Sen Hsu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Chang Gung medical journal Volume: 33 ISSN: 2072-0939 ISO Abbreviation: Chang Gung Med J Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088034 Medline TA: Chang Gung Med J Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 115-25 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cognition / physiology* Humans Insulin / physiology* Neuronal Plasticity / physiology* Receptor, Insulin / metabolism Synaptic Transmission / physiology* |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; EC 2.7.10.1/Receptor, Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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