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The role of insulin-like growth factor-1 in development of coronary no-reflow and severity of coronary artery disease in patients with acute myocardial infarction.
MedLine Citation:
PMID:  24799921     Owner:  NLM     Status:  PubMed-not-MEDLINE    
INTRODUCTION: Insulin-like growth factor-1 (IGF-1) has atheroprotective effects via reduction in oxidative stress, cellular apoptosis, pro-inflammatory signaling, and endothelial dysfunction.
AIM: We hypothesized that low levels of IGF-1 may be associated with the severity and extent of coronary artery disease and development of the coronary no-reflow phenomenon in patients with acute ST-elevation myocardial infarction (STEMI) and investigated the role of the IGF-1 molecule in the coronary no-reflow phenomenon and severity of coronary artery disease (CAD) in patients with acute STEMI in a tertiary hospital.
MATERIAL AND METHODS: The study was conducted among 113 patients undergoing primary percutaneous coronary intervention (PPCI) for STEMI, of whom 49 patients developed the no-reflow phenomenon. Coronary no-reflow was defined as Thrombolysis In Myocardial Infarction (TIMI) flow grade 2 or less after intervention. Insulin-like growth factor-1 levels were measured in both groups. The severity and extent of CAD were evaluated according to the Gensini and Syntax scores.
RESULTS: Although IGF-1 levels were lower in the no-reflow group, there was not a statistically significant difference between the no-reflow group and the control group (116.65 ±51.72 vs. 130.82 ±48.76, p = 0.130). Gensini and Syntax scores were higher in the no-reflow group. There was no association between Gensini and Syntax scores and IGF-1 levels (r = -0.071, r = 0.479, r = -0.158, p = 0.113).
CONCLUSIONS: In this study, IGF-1 levels were not statistically different between patients developing the no-reflow phenomenon and controls. There was no association between development of the no-reflow phenomenon and severity of CAD or IGF-1 levels. Nevertheless, large scale studies are needed to verify these results.
Ibrahim Faruk Akturk; Ahmet Arif Yalcin; Ismail Biyik; Nihan Turhan Caglar; Nilgun Isiksacan; Cetin Sarikamis; Fatih Uzun; Omer Celik; Ilker Murat Caglar
Publication Detail:
Type:  Journal Article     Date:  2014-03-23
Journal Detail:
Title:  Postępy w kardiologii interwencyjnej = Advances in interventional cardiology     Volume:  10     ISSN:  1734-9338     ISO Abbreviation:  Postepy Kardiol Interwencyjnej     Publication Date:  2014  
Date Detail:
Created Date:  2014-05-06     Completed Date:  2014-05-06     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  101272671     Medline TA:  Postepy Kardiol Interwencyjnej     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  -    
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