Document Detail


The role of insulin-like growth factor binding proteins.
MedLine Citation:
PMID:  17047378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Insulin-like growth factors (IGFs) are fundamental cell regulators with an evolutionary conserved role synchronising tissue growth, development and function according to metabolic conditions. Although structurally very similar to insulin, the IGFs act in a very different way as cell regulators. Whereas insulin is stored in a specific gland and released when needed, the IGFs are stored outside of cells with soluble binding proteins. A very complex system of six IGF binding proteins, each of which exists in various modified states and interacts with other proteins, provides a sophisticated system for conferring specificity to provide a finely tuned system for local regulation at the tissue level.
Authors:
Jeff Holly; Claire Perks
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-10-13
Journal Detail:
Title:  Neuroendocrinology     Volume:  83     ISSN:  0028-3835     ISO Abbreviation:  Neuroendocrinology     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-18     Completed Date:  2006-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0035665     Medline TA:  Neuroendocrinology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  154-60     Citation Subset:  IM    
Affiliation:
Department of Clinical Science at North Bristol, University of Bristol, Bristol, UK. jeff.holly@bristol.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Endopeptidases / metabolism
Humans
Insulin-Like Growth Factor Binding Proteins / classification,  physiology*
Signal Transduction / physiology*
Somatomedins / metabolism*
Chemical
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Proteins; 0/Somatomedins; EC 3.4.-/Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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