Document Detail

The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases.
MedLine Citation:
PMID:  21986983     Owner:  NLM     Status:  MEDLINE    
The maintenance of mucosal barrier equilibrium in the intestine requires a delicate and dynamic balance between enterocyte loss by apoptosis and the generation of new cells by proliferation from stem cell precursors at the base of the intestinal crypts. When the balance shifts towards either excessive or insufficient apoptosis, a broad range of gastrointestinal diseases can manifest. Recent work from a variety of laboratories has provided evidence in support of a role for receptors of the innate immune system, including Toll-like receptors 2, 4, and 9 as well as the intracellular pathogen recognition receptor NOD2/CARD15, in the initiation of enterocyte apoptosis. The subsequent induction of enterocyte apoptosis in response to the activation of these innate immune receptors plays a key role in the development of various intestinal diseases, including necrotizing enterocolitis, Crohn's disease, ulcerative colitis, and intestinal cancer. This review will detail the regulatory pathways that govern enterocyte apoptosis, and will explore the role of the innate immune system in the induction of enterocyte apoptosis in gastrointestinal disease.
Richard H Siggers; David J Hackam
Related Documents :
10586113 - Cytokines in the muscle tissue of idiopathic inflammatory myopathies: implications for ...
17632413 - Interferon gamma: friend or foe?
12857983 - Molecular regulation of t lymphocyte homeostasis in the healthy and diseased immune sys...
Publication Detail:
Type:  Journal Article; Review     Date:  2011-10-11
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  68     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-31     Completed Date:  2012-01-03     Revised Date:  2013-05-07    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3623-34     Citation Subset:  IM    
Division of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apoptosis / immunology*
Enterocytes / cytology,  physiology*
Gastrointestinal Diseases / immunology,  pathology*
Immunity, Innate / immunology*
Inflammation / immunology,  pathology*
Intestinal Mucosa / cytology,  immunology*,  pathology
NF-kappa B / immunology
Nod Signaling Adaptor Proteins / immunology
Signal Transduction / immunology
Toll-Like Receptors / immunology
Grant Support
Reg. No./Substance:
0/NF-kappa B; 0/Nod Signaling Adaptor Proteins; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Success rates and endotracheal tube insertion times of experienced emergency physicians using five v...
Next Document:  Neighborhood deprivation and prostate cancer mortality: a multilevel analysis from Sweden.