Document Detail


The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases.
MedLine Citation:
PMID:  21986983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The maintenance of mucosal barrier equilibrium in the intestine requires a delicate and dynamic balance between enterocyte loss by apoptosis and the generation of new cells by proliferation from stem cell precursors at the base of the intestinal crypts. When the balance shifts towards either excessive or insufficient apoptosis, a broad range of gastrointestinal diseases can manifest. Recent work from a variety of laboratories has provided evidence in support of a role for receptors of the innate immune system, including Toll-like receptors 2, 4, and 9 as well as the intracellular pathogen recognition receptor NOD2/CARD15, in the initiation of enterocyte apoptosis. The subsequent induction of enterocyte apoptosis in response to the activation of these innate immune receptors plays a key role in the development of various intestinal diseases, including necrotizing enterocolitis, Crohn's disease, ulcerative colitis, and intestinal cancer. This review will detail the regulatory pathways that govern enterocyte apoptosis, and will explore the role of the innate immune system in the induction of enterocyte apoptosis in gastrointestinal disease.
Authors:
Richard H Siggers; David J Hackam
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-10-11
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  68     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-31     Completed Date:  2012-01-03     Revised Date:  2013-05-07    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3623-34     Citation Subset:  IM    
Affiliation:
Division of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / immunology*
Enterocytes / cytology,  physiology*
Gastrointestinal Diseases / immunology,  pathology*
Humans
Immunity, Innate / immunology*
Inflammation / immunology,  pathology*
Intestinal Mucosa / cytology,  immunology*,  pathology
NF-kappa B / immunology
Nod Signaling Adaptor Proteins / immunology
Signal Transduction / immunology
Toll-Like Receptors / immunology
Grant Support
ID/Acronym/Agency:
P50 GM053789/GM/NIGMS NIH HHS; R01 DK083752/DK/NIDDK NIH HHS; R01 GM078238/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/NF-kappa B; 0/Nod Signaling Adaptor Proteins; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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