Document Detail

The role of inflammation and infection in preterm birth.
MedLine Citation:
PMID:  17205421     Owner:  NLM     Status:  MEDLINE    
Inflammation has been implicated in the mechanisms responsible for preterm and term parturition, as well as fetal injury. Out of all of the suspected causes of preterm labor and delivery, infection and/or inflammation is the only pathological process for which both a firm causal link with preterm birth has been established and a molecular pathophysiology defined. Inflammation has also been implicated in the mechanism of spontaneous parturition at term. Most cases of histopathological inflammation and histological chorioamnionitis, both in preterm and term labor, are sub-clinical in nature. The isolation of bacteria in the amniotic fluid, known as microbial invasion of the amniotic cavity, is a pathological finding; the frequency of which is dependent upon the clinical presentation and gestational age. This article reviews the role of inflammation in preterm and term parturition.
Roberto Romero; Jimmy Espinoza; Luís F Gonçalves; Juan Pedro Kusanovic; Lara Friel; Sonia Hassan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  25     ISSN:  1526-8004     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-05     Completed Date:  2007-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-39     Citation Subset:  IM    
Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
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MeSH Terms
Amnion / microbiology
Amniotic Fluid / microbiology,  virology
Chorioamnionitis / microbiology
Cytokines / physiology
DNA, Viral / analysis
Fetal Death / etiology
Fetal Diseases / etiology
Fetal Membranes, Premature Rupture / microbiology
Infection / complications*,  microbiology
Inflammation / complications*,  pathology,  physiopathology
Obstetric Labor, Premature / etiology*
Receptors, Immunologic
Reg. No./Substance:
0/Cytokines; 0/DNA, Viral; 0/Receptors, Immunologic

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