Document Detail

The role of inflammation in atrial fibrillation following open heart surgery.
MedLine Citation:
PMID:  18831903     Owner:  NLM     Status:  MEDLINE    
This study investigated the role of systemic inflammation in the development of atrial fibrillation (AF) after coronary artery bypass grafting (CABG). CABG was performed using cardiopulmonary bypass in 77 patients. Pre-operative AF was present in six patients (7.8%) and postoperative AF developed in 13 (18.3%) of the 71 patients with pre-operative sinus rhythm. Post-operative mediastinal drainage was significantly increased in patients with post-operative AF compared with those with sinus rhythm. Plasma E-selectin, P-selectin and vascular cell adhesion molecule levels were not significantly different between patients with pre- and post-operative sinus rhythm, those with pre-operative sinus rhythm and post-operative AF, and those with pre- and post-operative AF. There were significant differences between pre- and post-operative C-reactive protein, interleukin (IL)-6 and IL-10 levels within all three groups, but no differences in these parameters between the groups. Thus, in all groups there were significant alterations in mediators indicative of systemic inflammation following CABG, but comparisons between the groups revealed no differences predictive of AF.
S Canbaz; H Erbas; S Huseyin; E Duran
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of international medical research     Volume:  36     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-10-03     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1070-6     Citation Subset:  IM    
Department of Cardiovascular Surgery, Medical Faculty, Trakya University, Edirne, Turkey.
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MeSH Terms
Atrial Fibrillation* / etiology,  immunology
Biological Markers / metabolism
C-Reactive Protein / metabolism
Cardiopulmonary Bypass
Coronary Artery Bypass / adverse effects*
Inflammation / metabolism*
Interleukin-10 / blood
Interleukin-6 / blood
Middle Aged
Postoperative Complications
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 130068-27-8/Interleukin-10; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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