Document Detail

The role of the inflammasome in cellular responses to toxins and bacterial effectors.
MedLine Citation:
PMID:  17805541     Owner:  NLM     Status:  MEDLINE    
Invading pathogens are recognized by mammalian cells through dedicated receptors found either at the cell surface or in the cytoplasm. These receptors, like the trans-membrane Toll-like Receptors (TLR) or the cytosolic Nod-like Receptors (NLR), initiate innate immunity after recognition of molecular patterns found in bacteria or viruses, such as LPS, flagellin, or double-stranded RNA. Recognition of molecules produced only by a specific pathogen, such as a viral envelop protein or a bacterial adhesin does not appear to occur. Bacterial protein toxins, however, might compose an intermediate class. Considering the diversity of toxins in terms of structure, it is unlikely that cells respond to them via specific molecular recognition. It rather appears that different classes of toxins trigger cellular changes that are sensed by the cells as danger signals, such as changes in cellular ion composition after membrane perforation by pore-forming toxins or type III secretion systems. The signaling pathways triggered through toxin-induced cell alterations will likely play a role in modulating host responses to virulent bacteria. We will here describe the few studied cases in which detection of the toxin by the host cell was addressed. The review will include not only toxins but also bacteria effectors secreted by the bacterium in to the host cell cytoplasm.
Barbara Freche; Núria Reig; F Gisou van der Goot
Publication Detail:
Type:  Journal Article; Review     Date:  2007-09-06
Journal Detail:
Title:  Seminars in immunopathology     Volume:  29     ISSN:  1863-2297     ISO Abbreviation:  -     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308769     Medline TA:  Semin Immunopathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  249-60     Citation Subset:  IM    
Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Station 15, 1015, Lausanne, Switzerland.
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MeSH Terms
Bacterial Infections / immunology*
Bacterial Proteins / immunology
Bacterial Toxins / immunology*
Caspase 1 / immunology,  metabolism
Enzyme Activation / immunology
Inflammation / immunology*
Models, Immunological*
Multiprotein Complexes / immunology*
Nod Signaling Adaptor Proteins / immunology,  metabolism
Signal Transduction / immunology*
Toll-Like Receptors / immunology,  metabolism
Reg. No./Substance:
0/Bacterial Proteins; 0/Bacterial Toxins; 0/Multiprotein Complexes; 0/Nod Signaling Adaptor Proteins; 0/Toll-Like Receptors; EC 1

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