Document Detail

The role of infection and inflammation in sudden infant death syndrome.
MedLine Citation:
PMID:  19874217     Owner:  NLM     Status:  MEDLINE    
Sudden Infant Death Syndrome (SIDS) is the most common cause of post-neonatal mortality in the developed world. The exact cause of SIDS is likely to be multifactorial involving a critical developmental period, a vulnerable infant, and one or more triggers. Many SIDS infants have a history of viral illness preceding death. Prone sleep position, one of the leading risk factors, can increase airway temperature, as well as stimulate bacterial colonization and bacterial toxin production. Markers of infection and inflammation are often found on autopsy along with microbial isolates. Although the causal link between infection and SIDS is not conclusive, there is evidence that an infectious insult could be a likely trigger of SIDS in some infants.
Jane Blood-Siegfried
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunopharmacology and immunotoxicology     Volume:  31     ISSN:  1532-2513     ISO Abbreviation:  Immunopharmacol Immunotoxicol     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-06-25     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  8800150     Medline TA:  Immunopharmacol Immunotoxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  516-23     Citation Subset:  IM    
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MeSH Terms
Biological Markers / analysis
Infection / microbiology*,  pathology,  virology*
Inflammation / microbiology*,  pathology,  virology*
Sudden Infant Death / etiology*,  prevention & control
Grant Support
K01 NR010910/NR/NINR NIH HHS; K01 NR010910-03/NR/NINR NIH HHS
Reg. No./Substance:
0/Biological Markers

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