Document Detail


The role of NFAT5/TonEBP in establishing an optimal intracellular environment.
MedLine Citation:
PMID:  12729611     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
NFAT5/TonEBP, the most recently described member of the rel/NFkappaB/NFAT family of signal-dependent transcription factors, is activated by extracellular hypertonicity-a cellular stress of particular and perhaps unique physiologic relevance to cells of the renal medulla. Accumulating evidence suggests that NFAT5/TonEBP also functions in vivo under isotonic conditions as part of a ubiquitous regulatory mechanism that senses and adjusts available intracellular volume during cell growth to establish an intracellular environment appropriate for optimal cell proliferation.
Authors:
Steffan N Ho
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  413     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-05     Completed Date:  2003-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0644, USA. snho@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division
DNA-Binding Proteins / metabolism,  physiology*
Humans
Ions
Models, Biological
NFATC Transcription Factors
Osmosis
Phosphorylation
Signal Transduction
Transcription Factors / metabolism,  physiology*
Transcription, Genetic
Grant Support
ID/Acronym/Agency:
GM59651/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Ions; 0/NFATC Transcription Factors; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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