| The role of TWEAK/Fn14 in cardiac remodeling. | |
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MedLine Citation:
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PMID: 22752727 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The pathophysiological basis of heart failure is cardiac remodeling, a process that comprises structural and functional changes including cardiomyocyte proliferation, hypertrophy, necrosis, apoptosis, autophagy, interstitial fibrosis, contractile dysfunction and ventricular dilatation. Accumulating evidence demonstrate that tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is involved in the process by binding its receptor fibroblast growth factor-inducible molecule 14 (Fn14). In this review, we will discuss the potential role of the TWEAK/Fn14 axis in cardiac remodeling, elucidate its possible mechanisms and explore new therapeutic targets for heart failure. |
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Authors:
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Man-Yi Ren; Shu-Jian Sui |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-30 |
Journal Detail:
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Title: Molecular biology reports Volume: - ISSN: 1573-4978 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-7-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403234 Medline TA: Mol Biol Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Cardiology, Shandong Provincial Chest Hospital, 46 Lishan Road, Jinan, 250013, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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