Document Detail

The role of immune complexes in early syphilis and in the Jarisch-Herxheimer reaction.
MedLine Citation:
PMID:  6183866     Owner:  NLM     Status:  MEDLINE    
Circulating immune complexes (CIC) were detected in one of 11 patients with primary syphilis and in 5 of 12 patients with secondary syphilis. The level of CIC was significantly increased in patients with secondary syphilis. Four weeks later a significant decline in CIC was found. No relationship was demonstrated between CIC and affection of the skin, lymph nodes, or kidneys. An increased albumin excretion rate was demonstrated before treatment. No differences were found in the excretion rate of beta-2-microglobulin before or after treatment. Nineteen patients had a Jarisch-Herxheimer reaction during treatment. An increase in CIC was found in 5 patients and a decrease in 7 patients. No correlation could be demonstrated between the level of or changes in CIC and the severity of the Jarisch-Herxheimer reaction.
J Sølling; E From; C E Mogensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  62     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1982  
Date Detail:
Created Date:  1983-01-27     Completed Date:  1983-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  325-9     Citation Subset:  IM    
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MeSH Terms
Albumins / metabolism
Albuminuria / complications
Antigen-Antibody Complex / analysis*,  immunology,  physiology
Middle Aged
Molecular Weight
Syphilis / complications,  immunology*,  metabolism,  urine
beta 2-Microglobulin / metabolism
Reg. No./Substance:
0/Albumins; 0/Antigen-Antibody Complex; 0/beta 2-Microglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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