| The role of hysterotomy in the management of gestational trophoblastic neoplasia. | |
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MedLine Citation:
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PMID: 16681777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The management of late gestational trophoblastic disease recurrence is challenging. We present a case of a 16-year-old woman who was diagnosed with a gestational trophoblastic neoplasia 14 months after her hydatidiform mole pregnancy. A staging was performed revealing only an intramural lesion, which resembled a myoma, in the fundus of the uterus. Despite two course of methotrexate, the human chorionic gonadotropin (hCG) level increased slowly. The presentation was highly suggestive for a placental site trophoblastic tumor. A local resection of the tumor by hysterotomy was performed. Pathologic examination revealed a choriocarcinoma with tumor-free surgical margins. Subsequently, the patient received three cycles of EMA-CO (etoposide, methotrexate, actinomycin, cyclophosphamide, and vincristine). At present, 89 months after the hysterotomy, the patient is well, with no sings of recurrence. This report illustrates that it is mandatory to have a histologic diagnosis of chemoresistant gestational trophoblastic neoplasia before performing definitive surgery. |
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Authors:
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W A A Tjalma; J B Vermorken |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 16 ISSN: 1048-891X ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2006 Mar-Apr |
Date Detail:
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Created Date: 2006-05-09 Completed Date: 2006-10-12 Revised Date: 2006-11-07 |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 882-3 Citation Subset: IM |
Affiliation:
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Department of Gynecology, University Hospital Antwerpen (UZA), Antwerpen, Belgium. wiebren.tjalma@uza.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use Cyclophosphamide / therapeutic use Dactinomycin / therapeutic use Etoposide / therapeutic use Female Gestational Trophoblastic Neoplasms / diagnosis, drug therapy, surgery* Humans Hysterotomy* Methotrexate / therapeutic use Pregnancy Uterine Neoplasms / diagnosis, drug therapy, surgery* Vincristine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/EMA-CO protocol; 33419-42-0/Etoposide; 50-18-0/Cyclophosphamide; 50-76-0/Dactinomycin; 57-22-7/Vincristine; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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