Document Detail


The role of hypoxia-ischemia in term newborns with arterial stroke.
MedLine Citation:
PMID:  21397165     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The role of generalized hypoxia-ischemia in the genesis of perinatal focal arterial stroke remains puzzling. Animal studies have demonstrated that hypoxia-ischemia may alter blood flow through the ductus venosus, thereby increasing the risk for placental emboli entering the cerebral circulation. A retrospective review was performed of clinical records of all term newborns admitted to a tertiary perinatal center between January 1995 and May 2007 with acute arterial stroke on neuroimaging during the first week of life. Newborns were classified into 2 groups on the basis of neuroimaging abnormalities: stroke alone, or stroke and nonfocal hypoxic-ischemic brain injury. A total of 62 newborns had focal or multifocal stroke, 36 with stroke alone and 26 with stroke with nonfocal hypoxia-ischemia. Multiple risk factors for hypoxia-ischemia occurred in most newborns in both groups. These data indicate that hypoxia-ischemia may play a role in the genesis of stroke in the term newborn with or without evidence of nonfocal hypoxic-ischemic brain injury on neuroimaging.
Authors:
Aspasia Michoulas; S Nigel Basheer; Elke H Roland; Ken Poskitt; Steven Miller; Alan Hill
Related Documents :
17547615 - Sustained ventricular tachycardia in apical hypertrophic cardiomyopathy, midcavitary ob...
14228505 - New cytoplasmic components in arterial endothelia.
21527665 - Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation mic...
25448915 - The influence of atherosclerotic abdominal aorta on the shape of duplicated inferior ve...
8989075 - Validation of an inexpensive b-mode ultrasound device for detection of deep vein thromb...
7661475 - Central venous catheterization via persistent left superior vena cava.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  44     ISSN:  1873-5150     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Division of Neurology, Department of Pediatrics, University of British Columbia and British Columbia's Children's Hospital, Vancouver Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Care for child development: basic science rationale and effects of interventions.
Next Document:  PEHO syndrome: a study of five Argentinian patients.