Document Detail


The role of hypoxia-inducible factor 1 in atherosclerosis.
MedLine Citation:
PMID:  22569539     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Atherosclerosis is by far the most frequent underlying cause of coronary artery disease, carotid artery disease and peripheral arterial disease, and is associated with high morbidity and mortality. Hypoxic areas are known to be present in human atherosclerotic lesions, and lesion progression is associated with the formation of lipid-loaded macrophages, increased local inflammation and angiogenesis. The key regulator of hypoxia, hypoxia-inducible factor 1 (HIF-1), plays a key role in the progression of atherosclerosis by initiating and promoting the formation of foam cells, endothelial cell dysfunction, apoptosis, increasing inflammation and angiogenesis. The objective of this review is to summarise the pathological role of HIF-1 in the progression of atherosclerosis.
Authors:
Linggen Gao; Qian Chen; Xianliang Zhou; Li Fan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-8
Journal Detail:
Title:  Journal of clinical pathology     Volume:  -     ISSN:  1472-4146     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing, China.
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