| Role of the hypothalamic PVN in the regulation of renal sympathetic nerve activity and blood flow during hyperthermia and in heart failure. | |
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MedLine Citation:
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PMID: 20147365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothalamic paraventricular nucleus is a key integrative area in the brain involved in influencing sympathetic nerve activity and in the release of hormones or releasing factors that contribute to regulating body fluid homeostasis and endocrine function. The endocrine and hormonal regulatory function of the paraventricular nucleus is well studied, but the regulation of sympathetic nerve activity and blood flow by this region is less clear. Here we review the critical role of the paraventricular nucleus in regulating renal blood blow during hyperthermia and the evidence pointing to an important pathophysiological role of the paraventricular nucleus in the elevated renal sympathetic nerve activity that is a characteristic of heart failure. |
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Authors:
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Emilio Badoer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-02-10 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: 298 ISSN: 1522-1466 ISO Abbreviation: Am. J. Physiol. Renal Physiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-23 Completed Date: 2010-04-22 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: United States |
Other Details:
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Languages: eng Pagination: F839-46 Citation Subset: IM |
Affiliation:
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School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora 3083, Melbourne, Victoria, Australia. emilio.badoer@rmit.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fever / physiopathology* Heart Failure / physiopathology* Kidney / blood supply*, innervation* Paraventricular Hypothalamic Nucleus / physiology* Sympathetic Nervous System / physiology* |
| Comments/Corrections | |
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