| The role of human papillomavirus in common skin conditions: current viewpoints and therapeutic options. | |
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MedLine Citation:
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PMID: 21214125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A direct causal relationship between human papillomavirus (HPV) infection and cervical neoplasia is well-accepted, but the specific role of HPV in the pathogenesis of other cutaneous disorders is less clear. This article explores the role of HPV in 2 common disorders associated with considerable morbidity: external genital and perianal warts (EGWs) and actinic keratosis (AK). Because the potential role of HPV in the pathogenesis of EGW and AK may have implications that influence management, the available topical pharmacotherapy for each disorder also is reviewed. External genital and perianal warts represent a possible phenotypic expression of HPV infection and results from hyperkeratosis and hyperplasia of keratinocytes. The cell cycle disruption caused by low-risk anogenital HPV subtypes (eg, HPV-6, HPV-11) is similar to high-risk HPV subtypes, except low-risk HPV E6 and E7 proteins likely bind regulatory proteins with less affinity. Although UV light clearly has a primary causal role in the development of AK, new data suggest that HPV infection, particularly with 3-HPV subtypes, may serve as a cocarcinogen. By impairing normal DNA repair and apoptotic mechanisms, HPV may set the stage for later UV-induced transformation. It also has been suggested that HPV may increase the severity of AK lesions and contribute to their recurrence following therapy. |
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Authors:
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Mark G Lebwohl; Ted Rosen; Eggert Stockfleth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cutis; cutaneous medicine for the practitioner Volume: 86 ISSN: 0011-4162 ISO Abbreviation: Cutis Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2011-01-10 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006440 Medline TA: Cutis Country: United States |
Other Details:
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Languages: eng Pagination: suppl 1-11; quiz suppl 12 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Mt. Sinai School of Medicine, New York, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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administration & dosage Anus Diseases / drug therapy, virology Condylomata Acuminata / drug therapy, virology* Humans Keratosis, Actinic / drug therapy, virology* Papillomaviridae / isolation & purification* Recurrence Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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