Document Detail

The role of human papillomavirus in common skin conditions: current viewpoints and therapeutic options.
MedLine Citation:
PMID:  21214125     Owner:  NLM     Status:  MEDLINE    
A direct causal relationship between human papillomavirus (HPV) infection and cervical neoplasia is well-accepted, but the specific role of HPV in the pathogenesis of other cutaneous disorders is less clear. This article explores the role of HPV in 2 common disorders associated with considerable morbidity: external genital and perianal warts (EGWs) and actinic keratosis (AK). Because the potential role of HPV in the pathogenesis of EGW and AK may have implications that influence management, the available topical pharmacotherapy for each disorder also is reviewed. External genital and perianal warts represent a possible phenotypic expression of HPV infection and results from hyperkeratosis and hyperplasia of keratinocytes. The cell cycle disruption caused by low-risk anogenital HPV subtypes (eg, HPV-6, HPV-11) is similar to high-risk HPV subtypes, except low-risk HPV E6 and E7 proteins likely bind regulatory proteins with less affinity. Although UV light clearly has a primary causal role in the development of AK, new data suggest that HPV infection, particularly with 3-HPV subtypes, may serve as a cocarcinogen. By impairing normal DNA repair and apoptotic mechanisms, HPV may set the stage for later UV-induced transformation. It also has been suggested that HPV may increase the severity of AK lesions and contribute to their recurrence following therapy.
Mark G Lebwohl; Ted Rosen; Eggert Stockfleth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cutis     Volume:  86     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-01-10     Completed Date:  2011-01-24     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  suppl 1-11; quiz suppl 12     Citation Subset:  IM    
Department of Dermatology, Mt. Sinai School of Medicine, New York, New York, USA.
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MeSH Terms
Antiviral Agents / administration & dosage
Anus Diseases / drug therapy,  virology
Condylomata Acuminata / drug therapy,  virology*
Keratosis, Actinic / drug therapy,  virology*
Papillomaviridae / isolation & purification*
Severity of Illness Index
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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