Document Detail

The role of human and mouse Y chromosome genes in male infertility.
MedLine Citation:
PMID:  11097427     Owner:  NLM     Status:  MEDLINE    
It was suggested by Ronald Fisher in 1931 that genes involved in benefit to the male (including spermatogenesis genes) would accumulate on the Y chromosome. The analysis of mouse Y chromosome deletions and the discovery of microdeletions of the human Y chromosome associated with diverse defective spermatogenic phenotypes has revealed the presence of intervals containing one or more genes controlling male germ cell differentiation. These intervals have been mapped, cloned and examined in detail for functional genes. This review discusses the genes mapping to critical spermatogenesis intervals and the evidence indicating which are the most likely candidates underlying Y-linked male infertility.
N A Affara; M J Mitchell
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  23     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-26     Completed Date:  2001-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  630-45     Citation Subset:  IM    
Department of Pathology, University of Cambridge, UK.
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MeSH Terms
Chromosome Mapping
Gene Deletion
Infertility, Male / genetics*
Mice / genetics*
Sequence Homology
Spermatogenesis / genetics
Y Chromosome / genetics*

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