Document Detail

The role of the human genome project in disease prevention.
MedLine Citation:
PMID:  7845920     Owner:  NLM     Status:  MEDLINE    
The Human Genome Project has made it easier to genetically map and clone mutant genes which predispose to a great many human diseases. In addition to diseases inherited in a simple Mendelian fashion, there are many degenerative and infectious diseases, and sensitivities to environmental insults, in which the genetic make-up of an individual contributes to the course of the disease. Once a gene or genes associated with disease has been cloned, it is possible to design DNA-based diagnostics to detect altered forms of the gene which predispose to disease. The ability to predict the development of disease makes possible early intervention to limit the severity of a disease or to use gene therapy to cure inherited disorders.
M M Gottesman; F S Collins
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Preventive medicine     Volume:  23     ISSN:  0091-7435     ISO Abbreviation:  Prev Med     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-03-09     Completed Date:  1995-03-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0322116     Medline TA:  Prev Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  591-4     Citation Subset:  IM    
National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Disease Susceptibility
Genetic Markers
Genetic Testing
Genetics, Medical*
Human Genome Project*
Preventive Medicine*
Reg. No./Substance:
0/Genetic Markers

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